Pharmaniaga Simvastatin 40mg Tab

Manufacturer
Pharmaniaga Manufacturing Berhad,

Registraction Number
MAL20020477AZ

Content
Simvastatin 40 /mg

Indications
adjunctive therapy to diet and lifestyle in patients with primary hypercholesterolemia (including heterozygous familial), mixed dyslipidaemia, and to reduce cardiovascular risk in individuals with coronary heart disease (CHD) or high-risk profiles (e.g. diabetes, previous stroke, atherosclerosis)

Instructions

• Recommended dose: 40 /mg once daily in the evening. Maximum dose up to 80 /mg once at night, depending on LDL C response and patient tolerance

• Administration: Swallow the tablet whole with water; take at a consistent time each day, preferably after dinner or before bedtime; may be taken with or without food; avoid excessive grapefruit juice (>1 L/day) due to significant drug interactions 

• Precautions: Contraindicated in active liver disease, unexplained persistent transaminase elevations, pregnancy, and breastfeeding. Monitor liver enzymes (LFTs) and creatine kinase (CK) periodically. Use cautiously in renal/hepatic impairment and avoid combination with interacting drugs (e.g. fibrates, macrolides, azole antifungals, immunosuppressants)