Sporanox (itraconazole) is a triazole antifungal used to treat a variety of fungal infections:
Mucocutaneous & dermatological: tinea (pedis, corporis, cruris), pityriasis versicolor, onychomycosis (nail infections), oral or vaginal candidiasis.
Ophthalmic: fungal keratitis not responsive to other treatments.
Systemic: including aspergillosis, blastomycosis, histoplasmosis, cryptococcosis (including meningitis), sporotrichosis, chromomycosis, paracoccidioidomycosis in immunocompromised patients
How to take
Swallow the capsule whole, immediately after a full meal, to ensure proper absorption
Do not chew, crush, or open the capsule
Use an acidic drink (e.g., cola or orange juice) if stomach acidity is low
Avoid antacids or acid-blockers within 2 hours of dosing, as they can reduce absorption
Typical dosing regimens (may vary by country/label)
Vulvovaginal candidosis: 200 /mg twice in one day or 200 /mg once daily for 3 days.
Pityriasis versicolor: 200 /mg once daily for 7 days.
Tinea corporis/cruris: 100 /mg daily for 14 days or 200 /mg daily for 7 days.
Tinea pedis/manuum: 100 /mg daily for 30 days.
Oropharyngeal candidosis: 100 /mg daily for 15 days.
Fungal keratitis: 200 /mg daily for ~3 weeks.
Onychomycosis: 200 /mg daily for 3 months (continuous) or 200 /mg twice daily for 1 week monthly (pulse).
Systemic infections: 100–200 /mg daily, possibly increased to 400 /mg/day, for weeks to months
Missed dose
Take as soon as you remember, unless it is near the next scheduled dose. Do not double-dose .
Course completion
Complete the full prescribed course—even if symptoms resolve early—to prevent recurrence
Monitoring & precautions
Take the capsules with meals, maintain consistent schedule
Regular liver function tests are advised due to potential hepatotoxicity
Use effective contraception during treatment and for at least 2 months after, as itraconazole may cause fetal harm
Be aware of drug interactions, especially with medications affecting CYP3A4 (e.g., antacids, statins, macrolides, some antiarrhythmics) .
Malaysia
