Upper and lower respiratory tract infections: sinusitis, pharyngitis, tonsillitis, otitis media, bronchitis, and community-acquired pneumonia.
Skin and soft tissue infections.
Uncomplicated sexually transmitted infections: infections caused by Chlamydia trachomatis, non resistant Neisseria gonorrhoeae, and Haemophilus ducreyi (chancroid).
MAC prophylaxis or treatment in HIV patients, usually in combination with other agents—though not commonly used with the 500 /mg dose alone
Administration instructions: Swallow each tablet whole with water; do not chew, break or crush. Best taken at a consistent time each day, with or without food (meals may help reduce gastrointestinal discomfort)
Typical adult dosage:
As part of a standard 1,500 /mg total course: 500 /mg once daily for 3 days—or alternatively, 500 /mg on day /1 followed by 250 /mg daily on days /2–5 (note: with 500 /mg tablets you may modify accordingly)
For STDs (e.g. chlamydia, gonorrhoea): single 1 /g dose (two 500 /mg tablets at once)
Precautions and monitoring: Use with caution in patients with severe renal impairment (GFR /< /10 /mL/min) or significant liver disease; may need dosage adjustments. Monitor for QT prolongation in those with cardiac risk factors
Warnings: Avoid consuming alcohol during treatment due to potential enhanced side effects such as dizziness, fatigue, blurred vision and headache
Pregnancy & lactation: May be considered during pregnancy (animal studies show no fetal risk, though human data are limited); not advised during breastfeeding as the drug is excreted in breast milk
Malaysia
